gastric neuroendocrine tumors in bearded dragons

J Vet Diagn Invest.

Unable to load your collection due to an error By continuing to browse For more information view the This article describes a newly recognized highly malignant neoplastic entity in young bearded dragons (A review of the records at Northwest ZooPath and the Veterinary Medical Teaching Hospital at the University of Wisconsin identified 10 bearded dragons with gastric neuroendocrine tumors.

Gastric neuroendocrine carcinomas, and specifically somatostatinomas, have not been previously reported in bearded dragons, or other reptiles, and may be underdiagnosed due to inconsistent, ambiguous clinical signs.
All animals had neoplastic masses in their stomach, with metastasis to the liver. Simply select your manager software from the list below and click on download. M. Ritter, M. M. Garner, J. In such cases, the neoplasm is subclassified according to the hormone that predominates.In humans, functional subclassifications also relate neuroendocrine neoplasms to the presence or absence of clinical symptoms or syndromes resulting from hormone secretion by neoplastic cells.

Rhinitis in Dogs and Cats. Somatostatinoma should be considered in the differential for animals presenting with anorexia, weight loss, and anemia, particularly if there is concurrent, otherwise unexplained, hyperglycemia.We thank Roy Brown of Histologic Consulting Service for slide preparation, and Jamie Kinion and Christie Buie of Northwest ZooPath for data retrieval and photo editing, respectively. Please enable it to take advantage of the complete set of features! Briefly, formalin-fixed neoplastic tissue from the liver and stomach was subsequently retrimmed and submitted for transmission electron microscopy.

neuroendocrine granules within neoplastic cells. 2018 Jul 6;14(1):219. doi: 10.1186/s12917-018-1545-6.J Vet Diagn Invest.

Grossly, neoplastic masses were identified in 7 of the 9 animals, and all 7 had grossly visible masses in their stomach and liver. COVID-19 is an emerging, rapidly evolving situation.

2018 Jul;30(4):584-588. doi: 10.1177/1040638718779638. Name must be less than 100 characters

For further characterization, immunohistochemistry for protein gene product 9.5, neuron-specific enolase, endorphin, chromogranins A and B, synaptophysin, somatostatin, insulin, glucagon, gastrin, pancreatic polypeptide, and vasoactive intestinal peptide was performed on 5 animals.
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Somatostatinomas in humans are commonly associated with neurofibromatosis type 1 (Von Recklinghausen's disease), caused by a mutation in the tumor suppressor gene NF1, which results in decreased expression of neurofibromin. This product could help youAccessing resources off campus can be a challenge.

A. Chilton, E. R. Jacobson, and M. KiupelDiagnostic Center for Population and Animal Health and Department of Pathobiology and Diagnostic Investigation, Michigan State University, Lansing, MIVeterinary Medical Teaching Hospital, University of Wisconsin, Madison, WIDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FLDiagnostic Center for Population and Animal Health and Department of Pathobiology and Diagnostic Investigation, Michigan State University, Lansing, MIDiagnostic Center for Population and Animal Health and Department of Pathobiology and Diagnostic Investigation, Michigan State University, Lansing, MIVeterinary Medical Teaching Hospital, University of Wisconsin, Madison, WIDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL In humans, pancreatic somatostatinomas

Epub 2018 Jun 2.

The neoplastic masses were located primarily within and expanded the gastric submucosa (In all 5 bearded dragons, neoplasms had variable antigen-specific labeling of neoplastic cells for somatostatin (Electron microscopic examination of a gastric and a liver mass revealed 130- to 250-nm diameter spherical, membrane-bound, dense-core granules typical of neuroendocrine granules in the cytoplasm of neoplastic cells (Based on gross and microscopic findings, we conclude that the bearded dragons in this study had primary gastric neuroendocrine carcinomas with widespread metastasis, primarily to the liver.

Results of IHC and electron microscopy support the diagnoses of neuroendocrine carcinomas, and IHC results further allow us to classify these tumors as somatostatinomas, some of which had multihormonal expression.In reptiles, as in other animals, endocrine cells are either organized into discrete endocrine glands (pituitary, thyroid, parathyroid, adrenal, pancreatic islets) or distributed throughout many organ systems (e.g., lung, gastrointestinal tract, reproductive tract) in small clusters and individually as part of the dispersed neuroendocrine system.IHC provides the gold standard for confirmation of neuroendocrine origin and for functional subclassifications based on detectable secretory products.

ACVP members can log in in using their ACVP credentials below.J. Atypon microscopy performed on 1 tumor confirmed the presence of neuroendocrine granules within neoplastic cells. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. the site you are agreeing to our use of cookies. We also thank the Electron Microscopy Core Laboratory, Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, Florida. 1, 2, 4, 5, and 6).



This article describes a newly recognized highly malignant neoplastic entity in young bearded dragons (Pogona vitticeps), gastric neuroendocrine carcinomas, which readily metastasize.

Sections from each tissue were routinely stained with HE.An extended immunohistochemical (IHC) panel was performed on tissue from 5 bearded dragons (Nos.

Some of these IHC markers have previously been shown to exhibit cross-reactivity in other reptile species.Electron microscopy was performed on tissue from bearded dragon No. This panel included IHC to detect protein gene product 9.5 (PGP9.5), synaptophysin, gastrin, glucagon, chromogranins A and B, insulin, neuron-specific enolase (NSE), endorphin, somatostatin, vasoactive intestinal peptide (VIP), pancreatic polypeptide (PPP), and neurofibromin.

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